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KMID : 0857020060210010270
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Kosin Medical Journal
2006 Volume.21 No. 1 p.270 ~ p.274
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APC pathway including beta-catenin, c-MYC, and pS2 protein in intestinal type of Stomach Cancer
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Chang Hee-Kyung
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Abstract
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Background: A proposal that in normal colorectal epithelial cells, the adenomatous polyposis coli gene (APC) might modulate directly c-MYC transcription through beta-catenin/Tcf-4 was reported in 1998. It was reported that intestinal trefoil factor (TTF) which is the same family of pS as a gastric - specific tumor suppressor gene is related to beta-catenin. Method and
Material: To elucidate the applicability of APC pathway in stomach and relationship between this pathway and pS2, the expressions of pS2, c-MYC, and beta-catenin proteins wereevaluated by immunohistochemically in 30 cases of intestinal carcinoma of stomach which is morphologically close to colon cancer.
Restults: Their immunoreactivities were 56.7% for pS2, 43.3% for c-MYC, and 86.7% for beta-catenin proteins, respectively. Interestingly, positive staining of beta-catenin showed heterogenous pattern according to the depth of invasion. Tumor cells in the invading or infiltrating edges showed strong positivity, while thetumor cells in mucosa showed loss of the expression even ib the same tumors.
Conclusion: This results suggest that in intestinal carcinoma of stomach, beta-catenin involves in the tumor celll migration and invasion not as cell adhesion molecule but as tumor-suppressor molecule forming complex with APC. In addition, the expressions of c-MYC and pS2 was not correlated with the function of adhesion molecule of beta-catenin
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KEYWORD
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APC gene, beta-catenin, pS2, gastric canc
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